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Grégory Merlen on Muck Rack

Grégory Merlen

As seen in: Gut Journal, JHEP Reports
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Articles

TGR5 controls bile acid composition and gallbladder function to protect the liver from bile acid overload

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By Valeska Bidault-Jourdainne, Université Paris Saclay, Grégory Merlen, Mathilde Glénisson
| JHEP Reports Verified
Highlights • Reducing BA hydrophobicity improves outcomes after major hepatectomy in mice. • The BA receptor TGR5 controls BA pool composition, which is crucial for liver repair. • TGR5 targets the gallbladder to induce a hepatoprotective effect. • In patients, a more hydrophobic BA pool is associated with liver injury after hepatectomy.
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TGR5-dependent hepatoprotection through the regulation of biliary epithelium barrier function

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By Grégory Merlen, Université Paris-Sud, Nicolas Kahale, Jose Ursic-Bedoya
| Gut Journal Verified
TGR5-dependent hepatoprotection through the regulation of biliary epithelium barrier function Grégory Merlen1,2, Nicolas Kahale1,2, Jose Ursic-Bedoya1,2, Valeska Bidault-Jourdainne1,2, Hayat Simerabet1,2, Isabelle Doignon1,2, Zahra Tanfin1,2, Isabelle Garcin1,2, Noémie Péan1,2, Julien Gautherot1,2, Anne Davit-Spraul3,4, Catherine Guettier4,5, Lydie Humbert6, Dominique Rainteau7, Klaus Ebnet8, Christoph Ullmer9, Doris Cassio1,2, Thierry Tordjmann1,2 1 U1174, INSERM, Orsay, France 2 Université...
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TGR5-dependent hepatoprotection through the regulation of biliary epithelium barrier function

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By Université Paris-Sud, Grégory Merlen, Nicolas Kahale, Jose Ursic-Bedoya
| Gut Journal Verified
TGR5-dependent hepatoprotection through the regulation of biliary epithelium barrier function Grégory Merlen1,2, Nicolas Kahale1,2, Jose Ursic-Bedoya1,2, Valeska Bidault-Jourdainne1,2, Hayat Simerabet1,2, Isabelle Doignon1,2, Zahra Tanfin1,2, Isabelle Garcin1,2, Noémie Péan1,2, Julien Gautherot1,2, Anne Davit-Spraul3,4, Catherine Guettier4,5, Lydie Humbert6, Dominique Rainteau7, Klaus Ebnet8, Christoph Ullmer9, Doris Cassio1,2, Thierry Tordjmann1,2 1U1174, INSERM, Orsay, France 2Université...
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