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Keywords macrophage perivascular CAF heme oxygenase-1 stem-like CD8+ T cells CXCR4 CXCL12 tumor microenvironment chemotherapy and cancer Introduction The perivascular (Pv) niche is a dynamic tumor microenvironment (TME) composed of spatially organized immune and mesenchymal cell populations1,2,3 whose interactions influence cancer progression and therapeutic response.4,5,6,7,8,9 Pv tumor-associated macrophages (PvTAMs)4 are a central cellular component of the Pv niche, and they have been...
Abstract Toll-like receptor 9 (TLR9), primarily expressed in human dendritic and B cells, recognizes double-stranded DNA motifs from pathogens, initiating an inflammatory response. Recent studies have revealed TLR9's involvement beyond its conventional role in immune response, notably during the tumorigenesis of various cancers such as head and neck, cervical, and ovarian cancers.
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