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Gresin P. Hawse on Muck Rack

Gresin P. Hawse

As seen in: MDPI, BioRxiv
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Articles

Transcriptomic Changes During the Replicative Senescence of Human Articular Chondrocytes

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By Aysegul Atasoy-Zeybek, Gresin P. Hawse, Christopher V. Nagelli, Matthew P. Abdel
| MDPI
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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Transcriptomic changes during the replicative senescence of human articular chondrocytes

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By Christopher V. Nagelli, Matthew P. Abdel, Aysegul Atasoy-Zeybek, Gresin P. Hawse
| BioRxiv
Abstract Osteoarthritis (OA) is a degenerative joint disease and a leading cause of disability worldwide. Aging is a major risk factor for OA, but the specific mechanisms underlying this connection remain unclear. Although chondrocytes rarely divide in adult articular cartilage, they undergo replicative senescence in vitro which provides an opportunity to study changes related to aging under controlled laboratory conditions.
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