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Gretchen K Hubbard

As seen in: Color Research & Application
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Articles

MYC drives overexpression of telomerase RNA (hTR/TERC) in prostate cancer

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By Michael Rubenstein, Sarah J. Wheelan, Christopher M. Heaphy, Qizhi Zheng, David M Esopi, Gretchen K Hubbard, Maria C Moncaliano, Andrew Hruszkewycz, Ajay Vaghasia, Srinivasan Yegnasubramanian, Alan K Meeker, Mindy K Graham
| Color Research & Application Verified
Telomerase consists of at least two essential elements, an RNA component hTR or TERC that contains the template for telomere DNA addition, and a catalytic reverse transcriptase (TERT). While expression of TERT has been considered the key rate limiting component for telomerase activity, increasing evidence suggests an important role for the regulation of TERC in telomere maintenance and perhaps other functions in human cancer.
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