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Articles

Amyloid precursor protein induces reactive astrogliosis

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By Dragana Vukić, Isaac Onyango, Carlos Arias Verified, Gretsen Velezmoro
| biorxiv.org
Abstract We present in vitro and in vivo evidence demonstrating that Amyloid Precursor Protein (APP) acts as an essential instigator of reactive astrogliosis. Cell-specific overexpression of APP in cultured astrocytes led to remodelling of the intermediate filament network, enhancement of cytokine production and activation of cellular programs centred around the interferon (IFN) pathway, all signs of reactive astrogliosis.
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