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Pac13 is a Small, Monomeric Dehydratase that Mediates the Formation of the 3′-Deoxy Nucleoside of Pacidamycins

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By GSK Stevenage UK, Murray J. B, Rebecca J. M
| Color Research & Application Verified
The uridyl peptide antibiotics (UPAs), of which pacidamycin is a member, have a clinically unexploited mode of action and an unusual assembly. Perhaps the most striking feature of these molecules is the biosynthetically unique 3?-deoxyuridine that they share. This moiety is generated by an unusual, small and monomeric dehydratase, Pac13, which catalyses the dehydration of uridine-5?-aldehyde.
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