CCR Translations Bradley A. McGregor and Guru P. Sonpavde DOI: 10.1158/1078-0432.CCR-21-0139 Abstract Genomic alterations in penile squamous cell carcinoma (PSCC) appear similar to squamous cell carcinomas of the head and neck and esophagus but not lung, skin, bladder and cervix. PSCCs display genomic heterogeneity, low mutation burden and potentially actionable alterations in the Notch, DNA repair, kinase and cell cycle pathways. Received January 26, 2021. Revision received February 12, 2021.