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Bradley A McGregor

As seen in: Nature, Oxford Academic, BMJ Oncology, MDPI, The Lancet, NewsBreak, CURE Magazine, ONCOLOGY journal, OncLive, European Urology and
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Author Correction: Casdatifan shows durable response linked to HIF-2α biology in kidney cancer

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By Toni K. Choueiri, Jaime R. Merchan, Amita Patnaik, Alexandra Drakaki, Brian Rini Verified, Sun Young Rha, Jae Lee, Moshe C. Ornstein, Rohit Kumar, Clara Hwang, Yusra Shao, Pedro Barata, Bradley A McGregor, Paul Foster, Jianfen Chen, Melissa Eisen, Hunter Cole, Ben Weeder, Yinghui Guan, Jaskirat Singh, Angelo Kaplan, Soonweng Cho, Richard Markus, Omar Kabbarah, Rana R. McKay
| Nature Verified
Correction to: Nature https://doi.org/10.1038/s41586-026-10718-x Published online 1 July 2026 In the version of this article initially published, the name of Jaime Merchán was misspelled (Jamie Merchan) and is now amended in the HTML and PDF versions of the article.
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Casdatifan shows durable response linked to HIF-2α biology in kidney cancer

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By Toni K. Choueiri, Amita Patnaik, Alexandra Drakaki, Brian Rini Verified, Sun Young Rha, Jae Lee, Moshe C. Ornstein, Rohit Kumar, Clara Hwang, Pedro Barata, Bradley A McGregor, Paul Foster Verified, Jianfen Chen, Melissa Eisen, Hunter Cole, Ben Weeder, Yinghui Guan, Jaskirat Singh, Angelo Kaplan, Soonweng Cho, Richard Markus, Omar Kabbarah, Rana R. McKay, Jamie Merchan, Yusra Shao
| Nature Verified
Abstract Clear cell renal cell carcinoma (ccRCC) is largely driven by the transcription factor hypoxia-inducible factor 2α (HIF-2α)1. Here we show that monotherapy with casdatifan—an orally bioavailable, potent and selective HIF-2α inhibitor2—produces meaningful, durable antitumour activity with manageable safety in individuals with refractory metastatic ccRCC.
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Testosterone suppression and recovery with abiraterone/prednisone monotherapy after early discontinuation of LHRH-A in hormone sensitive prostate cancer | Prostate Cancer and Prostatic Diseases Original

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By Bradley A McGregor
| Nature Verified
Abstract Abiraterone acetate/prednisone (AAP) plus a luteinizing hormone releasing hormone agonist or antagonist (LHRH-A) is commonly used for treating high risk M0 or oligometastatic prostate cancer, but prolonged LHRH-A can be associated with delayed and incomplete testosterone (T) recovery after discontinuation.
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