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Guanchuan Lin

As seen in: Wiley Online Library, BioRxiv
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Articles

Deciphering the Oncogenic Landscape of Hepatocytes Through Integrated Single‐Nucleus and Bulk RNA‐Seq of Hepatocellular Carcinoma

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By Xuewen Zhou, Guanchuan Lin, Chaochao Luo, Huanhou Su
| Wiley Online Library Verified
1 Introduction Hepatocellular carcinoma (HCC) is the predominant histological subtype of primary liver cancer, accounting for over 80% of cases, and ranks as the third leading cause of cancer-related mortality worldwide.[1] HCC is a malignant tumor characterized by multi-gene dysregulation and significant heterogeneity, posing challenges to its diagnosis and therapy. Therefore, precise characterization of the oncogenic mechanisms in HCC is urgently needed in clinical practice.
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msCNVS: medium throughput single cell copy number variation sequencing with barcoded library construction free of preamplification toward clinical implementation

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By Bin Peng, Caiming Chen, Guanchuan Lin, Zhanying Dong
| BioRxiv
Abstract Single cell copy number variation sequencing (scCNV-seq) is valuable for genomic analysis of a variety of health and disease systems, yet the available methods either depend on either preamplification of the whole genome of each cell, special devices or untracable, which hinder scCNV-seq practice in clinics.
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