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Articles by Guanjun Chen
Gut microbiota in genetic diseases: from Mendelian disorders to complex traits
Abstract As a core component of the human microecosystem, the dynamic balance of the composition and function of gut microbiota is essential to host health. In recent years, numerous studies have demonstrated that gut dysbiosis is not only associated with metabolic diseases and immune disorders but also plays a pivotal role in the pathogenesis of hereditary diseases.
Deciphering the platinum resistance heterogeneity landscape of Ovarian cancer through integrated single-cell and spatial transcriptomics data
Abstract High tumor heterogeneity and platinum resistance are key drivers of poor prognosis in ovarian cancer (OV), yet platinum resistance heterogeneity within the OV tumor microenvironment remains incompletely characterized. Using five algorithms (AUCell, UCell, singscore, ssGSEA, AddModuleScore), we calculated a single-cell platinum resistance score (PRS) and stratified malignant cells into three PRS-based subtypes, followed by intercellular communication and pseudotime trajectory analyses.
Adaptive Stabilization of Mechanical Systems With Underactuation Degree One and Uncertainties Based on Controlled Lagrangians
Conflicts of Interest The author declares no conflicts of interest. Data Availability Statement All data generated or analysed during this study are included in this published article and all MATLAB codes for simulations are available on Github at https://github.com/guanjunchen/Adaptive_stabilization_algorithm. References 1, , and , “ Stabilization of Mechanical Systems Using Controlled Lagrangians,” in Proceedings of the 36th IEEE Conference on Decision and Control, 2356–2361, (1997).
SRSF10 promotes cisplatin resistance in bladder cancer via BIN1 Exon 12 retention and ANXA1 activation
Abstract RNA alternative splicing is a fundamental post-transcriptional mechanism that plays a key role in generating protein diversity. Previous studies from our group have shown that overexpression SRSF10 could promote liver cancer cell proliferation and invasion. However, its involvement in bladder cancer remains poorly understood. In the present study, we investigated SRSF10 expression using data from TCGA and GEO databases, immunohistochemistry, and proteomics.
Consensus-Based Power System State Estimation Algorithm Under Collaborative Attack
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Reinforcing the Stability of Cobalt-free Lithium-rich Layered Oxides via Li-poor Ni-rich Surface Transformation
Reinforcing the Stability of Cobalt-free Lithium-rich Layered Oxides via Li-poor Ni-rich Surface Transformation Lithium-rich layered oxides are one of the most promising cathode materials for lithium-ion batteries due to their super-high capacity and low cost. However, the extensive surface destructions, originated from the side reactions between the oxidative surface and the reductive electrolyte, lead to the fast capacity fading along with the inevitable voltage drop.
Hollow PtCu Nanoparticles Encapsulated into Carbon Shell via Mild Annealing of Metal-Organic Frameworks
Hollow PtCu Nanoparticles Encapsulated into Carbon Shell via Mild Annealing of Metal-Organic Frameworks Alloying Pt with less expensive 3d transition metal to form bimetallic nanoparticles (NPs) has been proven to be an ideal strategy for synthesis of catalysts, especially in the field of electrocatalysis. Unfortunately, these low-price 3d transition metals are easily leached from the alloy, thereby resulting in insufficient catalyst durability.
An Extracytoplasmic Function Sigma Factor Controls Cellulose Utilization by Regulating the Expression of an Outer Membrane Protein in Cytophaga hutchinsonii
Biodegradation Xia Wang, Weixin Zhang, Hong Zhou, Guanjun Chen, Weifeng Liu Maia Kivisaar, Editor DOI: 10.1128/AEM.02606-18 ABSTRACT The common soil cellulolytic bacterium known as Cytophaga hutchinsonii makes use of a unique but poorly understood strategy in order to utilize cellulose. While several genes have been identified as being an active part of the utilization of cellulose, the mechanism(s) by which C.
Synergistic Effects of Platinum-Cerium Carbonate Hydroxides- Reduced Graphene Oxide on Enhanced Durability for Methanol Electro-Oxidation
Synergistic Effects of Platinum-Cerium Carbonate Hydroxides- Reduced Graphene Oxide on Enhanced Durability for Methanol Electro-Oxidation Guanjun Chen, Zhengfei Dai, Lan Sun, Long Zhang, shuai liu, Hongwei Bao, Jinglei Bi, Shengchun Yang and Fei Ma Abstract The durability of electrocatalysts for methanol oxidation reaction (MOR) is currently the main concern to the commercial applications of direct methanol fuel cells (DMFCs).
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