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Zhijing Yin on Muck Rack

Zhijing Yin

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Articles

Deciphering the platinum resistance heterogeneity landscape of Ovarian cancer through integrated single-cell and spatial transcriptomics data

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By Ganghua Zhang, Guanjun Chen, Jianing Fang, Yiqi Tan, Ziwei Yin, Jingxin Yang, Le Li Zeng, Xiangyang Zeng, Biyao Jiang, Songshu Xiao, Yuxing Zhu, Ke Cao, Wenzhi Deng, Zhijing Yin, Jingyu Ou
| Nature Verified
Abstract High tumor heterogeneity and platinum resistance are key drivers of poor prognosis in ovarian cancer (OV), yet platinum resistance heterogeneity within the OV tumor microenvironment remains incompletely characterized. Using five algorithms (AUCell, UCell, singscore, ssGSEA, AddModuleScore), we calculated a single-cell platinum resistance score (PRS) and stratified malignant cells into three PRS-based subtypes, followed by intercellular communication and pseudotime trajectory analyses.
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