Guanwang Shen

Disclosure The authors declare that there are no conflicts of interests. Supporting Information Filename Description ins70121-sup-0001-figureS1.png195.4 KB Fig. S1 Expression levels of genes with tandem duplication events in fat body at different developmental stages. ins70121-sup-0002-tableS1.png640.4 KB Table S1 Characteristic data on Tret family members identified in Bombyx mori. ins70121-sup-0003-tableS2.png170.6 KB Table S2 Numbers of insect trehalose transporters.

1. Introduction Cellulose in coarse feed plays a crucial role in the dietary structure of cattle and sheep, as it is indispensable in the development of ruminants. Cellulose stimulates chewing and salivary secretion, promotes rumination, and enhances intestinal movement and health. Moreover, it aids in buffering rumen acidosis, regulates feed intake, and is crucial in the digestion of solid feed particles in the rumen [1].

1. Introduction The transcriptional control of cellular energy metabolism pathways is achieved through the coordinated action of multiple transcription factors and associated co-regulatory factors. Nuclear receptors are members of the transcription factor superfamily, which mediate the signaling of hormones, nutrients, metabolites, and redox signals into specific metabolic gene programs, and thus play important roles as regulatory factors in cellular energy generation.