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Guanyin Huang on Muck Rack

Guanyin Huang

As seen in: BMJ Oncology, BioRxiv
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Articles

Cortactin regulates metastatic dormancy of circulating tumor cells by suppressing mTOR-dependent senescence

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By Jianyang Hu, Binyu Zhang, Junhao Chen, Guanyin Huang
| BioRxiv
Abstract Metastatic dormancy often refers to the stable cell cycle arrest of disseminated tumor cells (DTCs) at distant sites. However, whether circulating tumor cells (CTCs) in the blood microenvironment can enter a dormant state prior to extravasation and becoming DTCs remains unclear.
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Circulating tumour cell clusters: isolation, biological significance and therapeutic implications

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By Yufan Yang, Guanyin Huang, Jingru Lian, Chunhao Long
| BMJ Oncology Verified
Introduction Cancer stands as a major leading cause of mortality globally, with distant metastasis accounting for nearly 90% of all cancer-related deaths.1 2 First identified by Ashworth in the mid-19th century, circulating tumour cells (CTCs) are considered metastatic precursors that leave the primary sites, transit in circulation and eventually give rise to distant metastasis.3 4 The blood circulation appears to be a harsh microenvironment for the survival of CTCs, as they have to resist...
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