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Guanying Zhang on Muck Rack

Guanying Zhang

As seen in: Nature, Virology Journal, BioRxiv, International Journal of Analytical Chemistry, Journal of Sensors
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Articles

Multimodal imaging reveals a lysosomal drug reservoir that drives heterogeneous distribution of PARP inhibitors

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By Restuadi Restuadi, Guanying Zhang, Daniel Marks, Paula Ortega-Prieto, Emily Doherty, Chad Whilding, Ivan Andrew, àlex Montoya, Bhavik Patel, Katie Tyson, Betheney R. Pennycook, Lauren Pendergast, Vincen Wu, Zoltan Takats, Nik Matthews, George Young, Priyanka Verma, Pavel V. Shliaha, Laurence Game, Boris Lenhard, Iain A. McNeish, Christina Fotopoulou, Alexis Barr, Paula Cunnea, Zoe Dare Hall, Carmen R. Moncayo, Nathalie Lambie, Louise Fets
| Nature Verified
Abstract For all drugs, effective target engagement requires sufficient intracellular concentrations of drug to be reached, but whether tumour heterogeneity impacts drug distribution and efficacy is poorly studied. Poly (ADP-ribose) polymerase (PARP) inhibitors have transformed treatment opportunities for women with high-grade serous ovarian carcinoma, but resistance remains a clinical hurdle in this highly heterogeneous tumour type.
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Correction: Immunogenicity of differentially glycosylated Marburg virus glycoproteins expressed in mammalian and insect cells - Virology Journal

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By Jie Li, Shaoyan Wang, Yue Cui, Liyuan Song, Zhenwei Song, Ping Huang, Xiangyang Chi, Ting Fang, Yunzhu Dong, Ruihua Li, Pengfei Fan, Yaoxing Wang, Lei Bi, Jianmin Li, Guanying Zhang, Changming Yu
| Virology Journal Verified
Correction Open access Published: 29 September 2025 Virology Journal volume 22, Article number: 307 (2025) Cite this article The Original Article was published on 11 August 2025 Correction: Virology Journal (2025) 22:275 In this article [1], Guanying Zhang should have been denoted as a corresponding author. The original article has been corrected. Reference Additional information Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
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Immunogenicity of differentially glycosylated Marburg virus glycoproteins expressed in mammalian and insect cells - Virology Journal

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By Jie Li, Shaoyan Wang, Yue Cui, Liyuan Song, Zhenwei Song, Ping Huang, Xiangyang Chi, Ting Fang, Yunzhu Dong, Ruihua Li, Pengfei Fan, Yaoxing Wang, Lei Bi, Jianmin Li, Guanying Zhang, Changming Yu
| Virology Journal Verified
To investigate the influence of glycosylation degree on the antigenicity and immunogenicity of the Marburg virus GPs, Angola-GP (KU978782) strain MARV GP ectodomains (including residues 1-637), containing the mucin-like domain (MARV GPΔTM) or deleting residues 264-425 to remove the mucin-like domain (MARV GPΔTM ΔMuc), were expressed in different cells.
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