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Guha Asthagiri Arunkumar on Muck Rack

Guha Asthagiri Arunkumar

As seen in: Nature, Science Magazine, American Society for Microbiology (ASM)
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Articles

Imprinting of serum neutralizing antibodies by Wuhan-1 mRNA vaccines - Nature

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By Chieh-Yu Liang, Zhuoming Liu, Yuhao Li, Guha Asthagiri Arunkumar, James Case, Seth J. Zost, Matthew Gagne, Shayne F. Andrew, Jason S. McLellan, Daniel Douek, Darin Edwards
| Nature Verified
Abstract Immune imprinting is a phenomenon in which prior antigenic experiences influence responses to subsequent infection or vaccination1,2. The effects of immune imprinting on serum antibody responses after boosting with variant-matched SARS-CoV-2 vaccines remain uncertain. Here, we characterized the serum antibody responses after mRNA vaccine boosting of mice and human clinical trial participants.
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Monoclonal Antibody Therapy Protects Pharmacologically Immunosuppressed Mice from Lethal Infection with Influenza B Virus

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By Bindumadhav M. Marathe, Guha Asthagiri Arunkumar, Peter Vogel, Jeremy Jones
| American Society for Microbiology (ASM)
Antiviral Agents Bindumadhav M. Marathe, Guha Asthagiri Arunkumar, Peter Vogel, Philippe Noriel Q. Pascua, Jeremy Jones, Richard J. Webby, Florian Krammer, Elena A. Govorkova DOI: 10.1128/AAC.00284-20 ABSTRACT Human influenza A and B viruses are highly contagious and cause similar illnesses and seasonal epidemics. Currently available antiviral drugs have limited efficacy in humans with compromised immune systems; therefore, alternative strategies for protection are needed.
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A serological assay to detect SARS-CoV-2 seroconversion in humans

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By Fatima Amanat, Daniel Stadlbauer, Guha Asthagiri Arunkumar, Giulio Kleiner
| Nature Verified
Abstract Here, we describe a serological enzyme-linked immunosorbent assay for the screening and identification of human SARS-CoV-2 seroconverters. This assay does not require the handling of infectious virus, can be adjusted to detect different antibody types in serum and plasma and is amenable to scaling.
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