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Guhan Venkataraman

As seen in: Nature, BioRxiv, India Currents
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Articles

Nanoparticle Enrichment Mass-Spectrometry Proteomics Identifies Protein Altering Variants for Precise pQTL Mapping

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By Karsten Suhre, Guhan Venkataraman, Harendra Guturu, Anna Halama
| BioRxiv
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Large-scale sequencing identifies multiple genes and rare variants associated with Crohn’s disease susceptibility - Nature Genetics

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By Christine Stevens, Guhan Venkataraman, Kai Yuan, Christopher Lamb, Nihr BioResource, Belgium IBD Consortium, Cedars-Sinai IBD
| Nature Verified
Abstract Genome-wide association studies (GWASs) have identified hundreds of loci associated with Crohn’s disease (CD). However, as with all complex diseases, robust identification of the genes dysregulated by noncoding variants typically driving GWAS discoveries has been challenging. Here, to complement GWASs and better define actionable biological targets, we analyzed sequence data from more than 30,000 patients with CD and 80,000 population controls.
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Bayesian mixture model for clustering rare-variant effects in human genetic studies

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By Guhan Venkataraman, Yosuke Tanigawa, Matti Pirinen, Manuel Rivas
| BioRxiv
Abstract Rare-variant aggregate analysis from exome and whole genome sequencing data typically summarizes with a single statistic the signal for a gene or the unit that is being aggre- gated. However, when doing so, the effect profile within the unit may not be easily characterized across one or multiple phenotypes.
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