Guifeng Hao on Muck Rack

Guifeng Hao

As seen in: Nature
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Articles

Iguratimod ameliorated collagen-induced arthritis by suppressing TNF-α/NF-κB signaling pathway and enhancing lymphangiogenesis in a murine model

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By Minmin Du, Xiaofen Xu, Xiaohui Cui, Yilin Chen, Peng Zhao, Qingqing Hu, Caifeng Wang, Jida Zhang, Changfeng Hu, Guifeng Hao
| Nature
Abstract Rheumatoid arthritis (RA) is a complex autoimmune joint disease characterized by persistent synovial inflammation and hyperplasia. The TNF-α/NF-κB signaling pathway is one of the most important inflammatory pathways involved in the onset and progression of RA. In addition, impaired lymphatic drainage plays a critical role in disease exacerbation. Iguratimod (IGU), a novel disease-modifying antirheumatic drug, has been shown to exert immunomodulatory effects.
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