Guilherme Dionir Back

1 INTRODUCTION The coronavirus disease 2019 (COVID-19) pandemic precipitated a series of unprecedented challenges for global health and society as a whole (Borghi-Silva et al., 2022). As the pandemic progressed, it became increasingly evident that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was not just a respiratory virus but a virus that also affected multiple organ systems, including the cardiovascular system. (Silva et al., 2021).

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Highlights • First study that evaluated early FMD in hospitalized patients with suspected and COVID-19. • Patients with COVID-19 had a significantly reduction in FMDmm and FMD%. • This population have early endothelial dysfunction. • Patients with COVID-19 spent more days in hospital and had a higher mortality rate. • FMDmm<0.26mm was significant predictor of mortality in patients with COVID-19.