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Guillaume A. Castillon on Muck Rack

Guillaume A. Castillon

As seen in: Nature, BioRxiv
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Articles

Dual activation of NLRP3 and pyrin inflammasomes mediates host responses to the human fungal pathogen Coccidioides

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By Priscila Mojica Rodriguez, Priscila Solera Rodríguez, Sara McArdle, Cameron J. Nowell, Janset Onyuru, Guillaume A. Castillon, Zbigniew Mikulski, Simon Goldstein, Aaron Carlin, Joshua Fierer, Theo N. Kirkland, Hal M. Hoffman, Sinem Beyhan, Ben Croker, Jonathan Rodrigo Erlich, Matthew M. Tate, Ahalya Ratnavel, Aanika Desai, Jane Symington
| Nature Verified
Abstract Coccidioides is a dimorphic fungal pathogen that grows as a mold in soil and produces infectious arthroconidia. Inhaled arthroconidia transition to spherules containing endospores in mammalian hosts. How distinct developmental forms of Coccidioides interact with immune cells remains poorly defined. Here, we show that arthroconidia activates TLR2 and induces NLRP3-pyrin inflammasomes in macrophages, while ferroptotic signaling promotes arthroconidia killing.
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Spatial and functional arrangement of Ebola virus polymerase inside phase-separated viral factories - Nature Communications

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By Jingru Fang, Guillaume A. Castillon, Sara McArdle, Mark Ellisman
| Nature Verified
Plasmids If not specified, NEB HiFi assembly was used for incorporation of DNA fragments into plasmid vector. To generate pCAGGS-mNG-HA-VP35, coding sequence of mNeonGreen (mNG) was PCR amplified from pmNeonGreenHO-3xFLAG-G (addgene#127914), while an N-terminal HA epitope tag was added to the mNG coding sequence. The resulting fragment was inserted upstream of the VP35 coding sequence in pCAGGS-VP35.
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Proximal Molecular Probe Transfer (PROMPT), a new approach for identifying sites of protein/nucleic acid interaction in cells by correlated light and electron microscopy

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By Guillaume A. Castillon, Sébastien Phan, Daniela Boassa, Junru Hu
| BioRxiv
New Results doi: https://doi.org/10.1101/2023.05.30.542936 Abstract The binding and interaction of proteins with nucleic acids such as DNA and RNA constitutes a fundamental biochemical and biophysical process in all living organisms. Identifying and visualizing such temporal interactions in cells is key to understanding their function.
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