Guinv Hu on Muck Rack

Guinv Hu

As seen in: Cell Reports Medicine
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Articles

MFGE8 induces anti-PD-1 therapy resistance by promoting extracellular vesicle sorting of PD-L1

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By Wenhui Wang, Jiming Chen, Shibo Wang, Jie Yang, Pengfei Yu, Jiang Wang, Shuya Qiao, Jianli Wang, Gensheng Zhang, Huajun Feng, Zhijian Cai, Xinhai Sun, Guinv Hu, Yuzhou He
| Cell Reports Medicine Verified
Keywords extracellular vesicles PD-L1 MFGE8 UBE4A anti-PD-1 therapy resistance Introduction Although immune checkpoint inhibitors anti-PD-1/anti-PD-L1 (αPD-1/αPD-L1) prolong the survival of various advanced tumor patients, the clinical response rate is low, ranging from 10% to 30%.1,2 Furthermore, some tumors, such as prostate and pancreatic cancer, are insensitive to αPD-1/αPD-L1 therapy.3,4 Therefore, it is crucial to decipher the mechanisms responsible for αPD-1/αPD-L1 therapy resistance.
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