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Guiying Cui

As seen in: Cell Press
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Articles by Guiying Cui

Permissive and nonpermissive channel closings in CFTR revealed by a factor graph inference algorithm

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By Alexander S. Moffett, Guiying Cui, Peter Thomas, William Hunt
| Cell Press Verified
We use the sum-product algorithm ( 21 Kschischang F.R. Frey B.J. Loeliger H.-A. Factor graphs and the sum-product algorithm. ) over the factor graph representing the sequence of states s to obtain the a posteriori distribution p(sk|y) . Meanwhile, the transition probability matrix Q and noise variance σ2 (and potentially the current amplitude A ) are unknown a priori and must be estimated from the data.
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An Ancient CFTR Ortholog Informs Molecular Evolution in ABC Transporters

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By Jeong Hee Hong, Daniel T. Infield, Guiying Cui, Yu-Wen Chung-Davidson
| Cell Press Verified
Highlights • Lampreys bear the oldest CFTR ortholog (Lp-CFTR), highly expressed in the intestine • Lp-CFTR has canonical CFTR structural domains and exhibits channel activity • Lp-CFTR anion channel function differs from recent CFTR orthologs in many ways • Lp-CFTR provides insights into evolution of function in this critical ABC protein Summary The cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride channel central to the development of secretory diarrhea and cystic...
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