Guiying Wang
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The circadian-microbiome-immune axis in colorectal cancer: mechanisms of spatiotemporal immunosuppression and chronotherapeutic horizons
Abstract Colorectal cancer (CRC) remains a major global oncological challenge, largely because most microsatellite-stable (MSS) tumors exhibit intrinsic resistance to immune checkpoint blockade (ICB). Emerging evidence suggests that the gut microbiome and host circadian rhythm jointly regulate mucosal homeostasis; however, their dynamic integration—defined here as the circadian-microbiome-immune axis—remains incompletely understood in CRC.
Machine learning to develop and validate a model for predicting the risk of lymph node metastasis in colorectal cancer patients
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Abstract Background: The presence of lymph node metastasis (LNM) serves as a critical determinant of prognosis in colorectal cancer (CRC), often correlating with markedly unfavorable clinical outcomes. Consequently, this investigation sought to construct and rigorously validate a machine learning (ML) algorithm capable of estimating LNM probability within the CRC population.
By Fang Liu, Yimin Wang Verified, Xiaohong Zheng, Feifei Wang, Chaoxi Zhou, Guiying Wang, Changhe Xia, Changjiang Xia, Zhanxue Zhang
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Frontiers
An Atomically Dispersed Pd Sub‐Metallene: Intermediate State of Single Atoms and Metal Bonds
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adma202504603-sup-0001-SuppMat.docx11.1 MB Supporting Information adma202504603-sup-0002-MovieS1.mpg13.7 MB Supplemental Movie 1 adma202504603-sup-0003-MovieS2.mpg13.7 MB Supplemental Movie 2 adma202504603-sup-0004-MovieS3.mp412.5 MB Supplemental Movie 3 References 1, , Chem. Soc. Rev. 2021, 50, 6700. 2, , Chem. Rev. 2020, 120, 1085. 3, , , , Adv. Mater. 2024, 36, 2210481. 4, , , , , Prog. Mater.
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