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Gukui Chen

As seen in: Nature, Dove Medical Press
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Articles by Gukui Chen

The bacteriophage transcription factor Gp53 suppresses cell division and regulates Pseudomonas aeruginosa physiology

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By Ying Li, Xiaomin Li, Gukui Chen, Lixin Yuan, Hailong Zhong, Min Hui, Yongfeng Sun, Yufei Han, Shuqin Zhou, Shiwei Wang, Weina Kong
| Nature Verified
Abstract Pseudomonas aeruginosa is a highly drug-resistant pathogen that poses a major challenge to clinical treatment. Bacteriophages encode diverse regulatory proteins that can alter host cellular processes during infection. Here we show that the ΦPA1019-encoded transcription factor Gp53 regulates bacterial physiology by targeting key host pathways. Gp53 expression reduces bacterial growth, motility, and biofilm formation, and causes filamentous cell morphology.
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A Case of Type 2 Diabetes Mellitus Complicated by Klebsiella pneumoniae Renal Abscess Leading to Infected Abdominal Aortic Pseudoaneurysm and Psoas Abscess

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By Shu Yang, Gukui Chen, Jia Jia
| Dove Medical Press
Back to Journals » Infection and Drug Resistance » Volume 19 Authors Yang S , Chen G, Jia J , Zhang J, Li Q, Jiao F Received 2 February 2026 Accepted for publication 18 June 2026 Published 25 June 2026 Volume 2026:19 597372 DOI https://doi.org/10.2147/IDR.S597372 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 3 Editor who approved publication: Dr Hazrat Bilal Shu Yang,1 Gukui Chen,2 Jia Jia,2 Jun Zhang,3 Qiang Li,4 Feiyan Jiao1 1Department of...
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Oligoribonuclease Contributes to Tolerance to Aminoglycoside and β-Lactam Antibiotics by Regulating KatA in Pseudomonas aeruginosa

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By Mei Li, Bin Xia, Zhenyang Tian, Gukui Chen
| asm.org
Mechanisms of Resistance Bin Xia, Mei Li, Zhenyang Tian, Gukui Chen, Chang Liu, Yushan Xia, Yongxin Jin, Fang Bai, Zhihui Cheng, Shouguang Jin, Weihui Wu DOI: 10.1128/AAC.00212-19 ABSTRACT Pseudomonas aeruginosa is an opportunistic bacterial pathogen and is intrinsically resistant to a variety of antibiotics. Oligoribonuclease (Orn) is a 3′-to-5′ exonuclease that degrades nanoRNAs. The Orn controls biofilm formation by influencing the homeostasis of cyclic-di-GMP.
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