Ying Li
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An optimized PanFlu-IOA-based mRNA vaccine targeting hemagglutinin confers broad-spectrum protection against heterosubtypic influenza viruses in mice
Abstract The rapid mutation rate of influenza viruses necessitates annual updates of vaccine formulations, underscoring the urgent need for a universal influenza vaccine. Current computationally optimized antigen strategies are mostly confined to certain subtypes and thus fail to elicit broad-spectrum immunity against heterosubtypic strains.
Oral microbiome collapse marks diabetic complications beyond glycemic control
Abstract Background: The metabolic memory phenomenon demonstrates that diabetic complications can progress independently of contemporaneous glycemic control, yet the upstream drivers sustaining this progression remain poorly defined. Whether the microbiome-metabolome axis participates in such post-glycemic mechanisms is unknown. Methods: We enrolled 154 participants across three disease stages: prediabetes (Pre.
Neutrophil Extracellular Traps Contribute to Peri-Implant Bone Loss: Insights Into Pro-Inflammatory Macrophage–Neutrophil Crosstalk
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The sequencing data have been deposited in the Genome Sequence Archive, accession number HRA018821, for single-cell RNA sequencing and HRA019038 for spatial transcriptomics. Supporting Information Filename Description jcpe70226-sup-0001-Appendices.docxWord 2007 document , 9.7 MB Appendix S1: Supporting information.
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