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Gunther Wennemuth on Muck Rack

Gunther Wennemuth

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Articles

3D structure and in situ arrangements of CatSper channel in the sperm flagellum - Nature Communications

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By Huafeng Wang, Polina Lishko, Daniela Nicastro, Jean-Ju Chung, Caroline Wiesehoefer, Gunther Wennemuth
| Nature Verified
Abstract The sperm calcium channel CatSper plays a central role in successful fertilization as a primary Ca2+ gateway. Here, we applied cryo-electron tomography to visualize the higher-order organization of the native CatSper complex in intact mammalian sperm. The repeating CatSper units form long zigzag-rows along mouse and human sperm flagella. Above each tetrameric channel pore, most of the extracellular domains form a canopy that interconnects to a zigzag-shaped roof.
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