Guntram A. Grassl

Abstract Clostridioides difficile infection (CDI) remains a leading cause of antibiotic-associated diarrhoea, with high recurrence rates and limited treatment options that preserve gut microbiota. Current treatments, including vancomycin, further disrupt the already compromised gut microbiota, often prolonging dysbiosis and increasing the risk of colonization by resistant pathogens. This study demonstrates that argyrin B exhibits potent activity against C.

Loading metrics Open Access Peer-reviewed Research Article Citation: Schwermann N, Haller R, Koch S, Grassl GA, Winstel V (2023) Pathogen-driven nucleotide overload triggers mitochondria-centered cell death in phagocytes. PLoS Pathog 19(12): e1011892. https://doi.org/10.1371/journal.ppat.1011892 Editor: Anders P. Hakansson, Lunds universitet Medicinska fakulteten, SWEDEN Received: July 28, 2023; Accepted: December 8, 2023; Published: December 29, 2023 Copyright: © 2023 Schwermann et al.

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