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Guo none Xueshui

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Articles

Reduction of RAD23A extends lifespan and mitigates pathology in TDP-43 mice

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By Insuk Byun, Jiyeon Chun, Guo none Xueshui, Ravindra none Prajapati
| BioRxiv
Abstract Protein misfolding and aggregation are cardinal features of neurodegenerative disease (NDD) and they contribute to pathophysiology by both loss-of-function (LOF) and gain-of-function (GOF) mechanisms. This is well exemplified by TDP-43 which aggregates and mislocalizes in several NDDs. The depletion of nuclear TDP-43 leads to reduction in its normal function in RNA metabolism and the cytoplasmic accumulation of TDP-43 leads to aberrant protein homeostasis.
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