Guo-Ying Liu

Research BMJ 2024; 385 doi: https://doi.org/10.1136/bmj-2023-077890 Cite this as: BMJ 2024;385:e077890 Guo-Ying Liu, associate professor1 2, Yan-Fang Ye, assistant research fellow1, Yao-Fei Jiang, doctoral student3, Gina Jinna Chen, assistant professor4, Wei-Xiong Xia, professor1, Yi-Sheng Huang, professor5, Tian-Sheng Gao, professor4, Yi-Min Liu, professor2, Ya-Ting Hou, physician5, Jian-Fei Li, physician5, Jia-Hao Liu, physician6, Nian Lu, postdoctoral fellow6, Chang-Long Chen, associate...

Palladium-catalyzed alkynylation of allylic gem-difluorides† Herein, a palladium-catalyzed regioselective alkynylation, esterification, and amination of allylic gem-difluorides via C–F bond activation/transmetallation/β-C elimination or nucleophilic attack has been achieved. This innovative protocol showcases an extensive substrate range and operates efficiently under mild reaction conditions, resulting in high product yields and Z-selectivity.

Significant advancements in synthesis of monofluoroalkenes via palladium-catalyzed reactions involving allylic gem-difluorides and diverse nucleophiles have been achieved. This method allows regioselective arylation, alkylation, allylation, alkenylation, and hydrogenation of allylic gem-difluorides, yielding high Z-selectivity and favorable product yields under mild conditions. Tolerating various functional groups, these transformations utilize a common Pd–OH intermediate.