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Guo-Ying Sun

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Spermidine mitigates acute lung injury through activation of the Keap1-Nrf2-ARE pathway

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By Wei Zhou, Xiao-Ming Li, Wei-Yi Li, Hua Tan, Can Zhou, Yun-Fu Wei, Zhi-Ping Hu, Jun-Xiang Xiong, Guo-Ying Sun
| Nature Verified
Abstract Acute lung injury (ALI) is a critical pulmonary disorder precipitated by infection or trauma, characterized by heightened inflammation and oxidative stress. The nuclear factor erythroid 2-related factor 2 (Nrf2) is a pivotal transcription factor that regulates these processes and may act as a significant modulator in ALI. Spermidine, a naturally occurring polyamine with antioxidant and anti-inflammatory properties, is postulated to mitigate ALI by activating Nrf2.
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