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Abstract Esophageal cancer, a serious malignancy, is primarily treated with radiotherapy (RT). Accurate delineation of gross tumor volume (GTV) and clinical target volume (CTV) is essential, yet manual contouring is time-consuming and automatic methods remain challenging. Adaptive radiotherapy enables personalized target adjustments, but tumor changes following initial RT complicate delineation, and automatic second-phase replanning is underexplored.
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