Citation: Qi R, Teng W, Yang X, Han P, Shaytan AK, Liu B (2026) scRADAR: Dissecting intratumoral drug response heterogeneity at single-cell resolution via mechanism-guided prototype routing. PLoS Comput Biol 22(6): e1014392. https://doi.org/10.1371/journal.pcbi.1014392 Editor: Guang-Zhong Wang, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, CHINA Received: April 15, 2026; Accepted: June 2, 2026; Published: June 26, 2026 Copyright: © 2026 Qi et al.