Guodi Wu on Muck Rack

Guodi Wu

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Articles

Prostaglandin E2 alleviates acetaminophen-induced liver injury through DDIT4-enhanced autophagy regulated by circLima1 / miR-486

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By Chao Chen, Jun Guan, Shanshan Wu, Yanli Ren, Jing L. Wang, Xinyu Gu, Zhi Chen, Haihong Zhu, Guodi Wu
| Nature Verified
Abstract Acetaminophen (APAP) overdose is a leading cause of acute liver injury (AILI). While Prostaglandin E2 (PGE2) protects against various forms of acute hepatitis, its underlying mechanisms and the role of circRNA-mediated regulatory networks in AILI remain to be elucidated. AILI was induced in mice by administration of 500 mg/kg APAP, with or without 16,16-dimethyl PGE2 (dmPGE2) pretreatment.
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