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Guoteng Liu

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Articles

COSA-1–SLX-4 interaction directly links crossover designation with Holliday junction resolution

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By En-Ze Li, Jing Wang, Jiaxi Li, Xuezhen Wu, Anton Gartner, Hongtao Zhang, Guoteng Liu, Wencong Nan
| Science Magazine Verified
Abstract Crossover (CO) formation between homologous chromosomes is essential for genetic diversity and accurate meiotic chromosome segregation. This process involves two key steps: the designation of a subset of meiotic double-strand breaks to CO-designated sites and subsequent CO resolution by Holliday junction (HJ) resolvase. However, how these steps are functionally coupled remains elusive.
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