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Articles by Guoxin Ying
Arf-like Protein 2 (ARL2) Controls Microtubule Neogenesis during Early Postnatal Photoreceptor Development
Open AccessArticle by Cecilia D. Gerstner 1, Michelle Reed 1, Tiffanie M. Dahl 1, Guoxin Ying 1, Jeanne M. Frederick 1 and Wolfgang Baehr 1,2,3,* 1 Department of Ophthalmology, University of Utah Health Science Center, Salt Lake City, UT 84132, USA 2 Department of Neurobiology & Anatomy, University of Utah, Salt Lake City, UT 84112, USA 3 Department of Biology, University of Utah, Salt Lake City, UT 84112, USA * Author to whom correspondence should be addressed.
Deletion of CEP164 in mouse photoreceptors post-ciliogenesis interrupts ciliary intraflagellar transport (IFT)
Fig 5. rodCep164-/- scotopic and photopic ERG and fate of cones. A, control (blue) and rodCep164-/- mice (red) were dark-adapted overnight and exposed under scotopic conditions to flashes of 1.4 log cd s/m2 at P16, P21 and P30 (n = 4–14). Note knockout a- and b- wave amplitudes were diminished at all ages. B, statistical evaluation of amplitudes of control and knockout CEP164 scotopic ERG a-waves at P15, P21 and P30 as measured in A.
Effect of conditional deletion of cytoplasmic dynein heavy chain DYNC1H1 on postnatal photoreceptors
Loading metrics Open Access Peer-reviewed Research Article Tiffanie M. Dahl, Michelle Reed, Cecilia D. Gerstner, Guoxin Ying, Wolfgang Baehr Tiffanie M. Dahl, Michelle Reed, Cecilia D.
Deletion of both centrin 2 (CETN2) and CETN3 destabilizes the distal connecting cilium of mouse photoreceptors
Guoxin Ying‡1, Jeanne M. Frederick‡ and Wolfgang Baehr‡,§,¶2 From the ‡Department of Ophthalmology, University of Utah Health Science Center, Salt Lake City, Utah 84132, the §Department of Neurobiology and Anatomy, University of Utah, Salt Lake City, Utah 84112, and the ¶Department of Biology, University of Utah, Salt Lake City, Utah 84132 ↵1 To whom correspondence may be addressed. E-mail: g.ying{at}utah.edu. ↵2 Recipient of an RPB Senior Investigator award and an RPB Nelson Trust award.
Deletion of both centrin 2 (CETN2) and CETN3 destabilizes the distal connecting cilium of mouse photoreceptors
Guoxin Ying1, Jeanne M. Frederick2 and Wolfgang Baehr3* 1University of Utah, United States 2University of Utah 3Ophthalmology, University of Utah, United States ↵* Corresponding author; email: wbaehr{at}hsc.utah.edu Author contributions: G.Y., J.M.F., and W.B. conceptualization; G.Y. data curation; G.Y., J.M.F., and W.B. formal analysis; G.Y. and W.B. investigation; G.Y. and J.M.F. methodology; J.M.F. validation; W.B. funding acquisition; W.B. project administration.
The small GTPase RAB28 is required for phagocytosis of cone outer segments by the murine retinal pigmented epithelium
RAB28, a member of the RAS oncogene family, is a ubiquitous, farnesylated, small GTPase of unknown function present in photoreceptors and the retinal pigmented epithelium (RPE). Nonsense mutations of the human RAB28 gene cause recessive cone-rod dystrophy 18 (CRD18), characterized by macular hyperpigmentation, progressive loss of visual acuity, RPE atrophy, and severely attenuated cone and rod electroretinography (ERG) responses.
The small GTPase Rab28 is required for phagocytosis of cone outer segments by the murine retinal pigmented epithelium
Rab28, a member of the RAS oncogene family is a ubiquitous, farnesylated, small GTPase of unknown function present in photoreceptors and the retinal pigmented epithelium (RPE). Nonsense mutations of the human RAB28 gene cause recessive cone-rod dystrophy 18 (CRD18), characterized by macular hyperpigmentation, progressive loss of visual acuity, RPE atrophy and severely attenuated cone and rod electroretinography (ERG) responses.
The small GTPase Rab28 is required for phagocytosis of cone outer segments by the murine retinal pigmented epithelium
The small GTPase Rab28 is required for phagocytosis of cone outer segments by the murine retinal pigmented epithelium Guoxin Ying1, Karsten Boldt2, Marius Ueffing3, Cecilia D. Gerstner4, Jeanne M.
Small GTPases Rab8a and Rab11a Are Dispensable for Rhodopsin Transport in Mouse Photoreceptors
Citation: Ying G, Gerstner CD, Frederick JM, Boye SL, Hauswirth WW, Baehr W (2016) Small GTPases Rab8a and Rab11a Are Dispensable for Rhodopsin Transport in Mouse Photoreceptors. PLoS ONE 11(8): e0161236. doi:10.1371/journal.pone.0161236 Copyright: © 2016 Ying et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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