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Guoyue Wan

As seen in: Frontiers, Cell Press
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Articles by Guoyue Wan

Integrated time-series multi-omics reveals temporal reprogramming and inter-organ divergence in diabetic cardiorenal syndrome

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By Shan-shan Gao, Guoyue Wan, Qi Wang, Jing An, Qingmei Yang, Chuyu Liu, Yulan Cai
| Frontiers
Abstract Diabetes induces progressive transcriptional reprogramming in the heart and kidney, yet their tissue-specific temporal dynamics and cellular mechanisms remain incompletely understood. In this study, we employed a longitudinal design with dense sampling intervals, performing time-series bulk RNA-seq on heart and kidney tissues across six bi-weekly intervals from Control, high-fat diet (HF), diabetes (DM), and insulin-treated (INS) mice (n=38 total samples).
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Cryo-EM study of patched in lipid nanodisc suggests a structural basis for its clustering in caveolae

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By Xiang Zhang, Yitian Luo, Guoyue Wan
| Cell Press Verified
Highlights • The Hedgehog receptor Ptc1 from mouse was reconstituted into lipid nanodisc • Structure of Ptc1 in lipid membrane is overall similar to that in amphipol/detergents • An N-terminal helix is important but not essential for Ptc1 activity • Different homodimers are observed along with different membrane curvatures Summary The 12-transmembrane protein Patched (Ptc1) acts as a suppressor for Hedgehog (Hh) signaling by depleting sterols in the cytoplasmic membrane leaflet that are...
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