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Guro K Sandvik on Muck Rack

Guro K Sandvik

As seen in: BioRxiv
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Articles

Investigating antiviral pathways in Atlantic salmon cells through interferon receptor knockouts via CRISPR-Cas9

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By Thomas Harvey, Oystein Evensen, Gareth Benjamin Gillard, Guro K Sandvik
| BioRxiv
Abstract In Atlantic salmon (Salmo salar), infectious salmon anemia virus (ISAV) and infectious pancreatic necrosis virus (IPNV) evade host immune response through complex antagonistic mechanisms. Type I interferons (IFNs) play a pivotal role in antiviral defense by signaling through heterodimeric receptors to activate the JAK-STAT pathway and drives the expression of interferon-stimulated genes (ISGs).
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