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Gürsel Çalışkan on Muck Rack

Gürsel Çalışkan

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Articles

Autism-like behavior induced by conditional ablation of the Bassoon gene in GABAergic interneurons

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By Anil Annamneedi, Carolina Montenegro-Venegas, Armand Blondiaux, Nikhil Tiwari, Judith C. Kreutzmann, Lucie Pellissier, Anna Fejtova, Sanja Mikulovic, Markus Fendt, Eckart D. Gundelfinger, Oliver Stork, Gürsel Çalışkan, Endre Levente Marosi, Misbah Razzaq
| Nature Verified
Abstract Synaptic dysfunction and resulting imbalance of excitatory vs. inhibitory transmission are fundamental aspects of autism spectrum disorders (ASD). Here we addressed the role of inhibitory synapse disturbances in ASD employing mice with a conditional ablation in GABAergic forebrain interneurons of the presynaptic active zone scaffolding protein Bassoon (Bsn), a key factor in synaptic development, activity and maintenance.
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