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F1000Prime Recommended Article: Hydroxyethyl starch 130/0.42 versus Ringer's acetate in severe sepsis. Total Score (stars): 41

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By Guttormsen AB, Madsen KR, Møller MH, Elkjær JM
| f1000.com
BACKGROUND: Hydroxyethyl starch (HES) [corrected] is widely used for fluid resuscitation in intensive care units (ICUs), but its safety and efficacy have not been established in patients with severe sepsis. METHODS: In this multicenter, parallel-group, blinded trial, we randomly assigned patients with severe sepsis to fluid resuscitation in the ICU with either 6% HES 130/0.42 (Tetraspan) or Ringer's acetate at a dose of up to 33 ml per kilogram of ideal body weight per day.
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Hydroxyethyl starch 130/0.42 versus Ringer's acetate in severe sepsis

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By Guttormsen AB, Madsen KR, Møller MH, Elkjær JM
| ncbi.nlm.nih.gov
Background: Hydroxyethyl starch (HES) [corrected] is widely used for fluid resuscitation in intensive care units (ICUs), but its safety and efficacy have not been established in patients with severe sepsis. Methods: In this multicenter, parallel-group, blinded trial, we randomly assigned patients with severe sepsis to fluid resuscitation in the ICU with either 6% HES 130/0.42 (Tetraspan) or Ringer's acetate at a dose of up to 33 ml per kilogram of ideal body weight per day.
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