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Articles by Guy Hans
TRPM3 mediates spontaneous pain and mechanical allodynia in a mouse model of chronic orofacial neuropathy
While classically the majority of TN cases in humans were considered to be sporadic and evoked by compression of the trigeminal nerve, there is growing evidence, including familial occurrences, that genetic factors may contribute to the pathogenesis of TN in a subset of patients. To date, we are not aware of any published genome-wide association studies that identify genetic associations with genome-wide significance for TN.
Hyperbaric Oxygen Therapy in Managing Chronic Pain Syndromes – A Systematic Review
Back to Journals » Journal of Pain Research » Volume 19 Review Musculoskeletal Pain/Rehabilitation and Neuropathic Pain Authors Leys AM , Hans GH , Saldien V , Wildemeersch D Received 19 January 2026 Accepted for publication 11 March 2026 Published 24 March 2026 Volume 2026:19 Pages 1—16 DOI https://doi.org/10.2147/JPR.S597243 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Alaa Abd-Elsayed Anna-Maria Leys,1 Guy...
Frontiers | Large-scale real-world data on a multidisciplinary approach to spinal cord stimulation for persistent spinal pain syndromes: first evaluation of the Neuro-Pain ® Nationwide Screening and Followup Interactive Register
Keywords: Spinal Cord Stimulation, neuropathic pain, Long-term data, Chronic Pain, Neurostimulator, nation-wide dynamic register Received: 15 Oct 2023; Accepted: 26 Feb 2024. Copyright: © 2024 Bernaerts, Roelant, Lecomte, Moens, Van Buyten, Billet, Bryon, Puylaert, Turgay, Malone, Theys, Van Zundert, Berquin, Crombez, De Coster, Vangeneugden, Ly, Louagie and Hans. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Objective Nociceptive Assessment in Ventilated ICU Patients: A Feasibility Study Using Pupillometry and the Nociceptive Flexion Reflex
Many critically ill patients in the Intensive Care Unit (ICU) are prone to experience pain during daily care or during diagnostic or therapeutic procedures. Substandard nociceptive evaluation and consequent suboptimal pain management may increase stress and anxiety1. Persistent pain not only increases circulating catecholamines, compromises tissue perfusion and reduces oxygen delivery2 but also activates catabolic hypermetabolism, thus contributing to hyperglycemia, lipolysis and muscle loss.
Impact of topical 5% lidocaine-medicated plasters on sleep and quality of life in patients with postherpetic neuralgia
Aim: To determine the impact of 5% lidocaine-medicated plasters on sleep, quality of life and pain in 265 patients with postherpetic neuralgia (PHN). Patients & methods: An 8-week, open-label arm of a double-blind controlled withdrawal study. Results: Patients treated with 5% lidocaine had less trouble falling asleep, used less sleep medication, had fewer awakenings due to pain at night or in the morning and their perception of quality of life was improved.
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