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Gw McElfresh

As seen in: Nature, BioRxiv
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Articles

Antigenic stimulation in conjunction with cytokine is required for mediating IL-17A production in human MAIT cells

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By Se-Jin Kim, Dylan Kain, Deborah A. Lewinsohn, Gwendolyn M. Swarbrick, Meghan Cansler, Benjamin N. Bimber, Gw McElfresh, Emily Wong, Sharon Khuzwayo, Thomas Riffelmacher, David M Lewinsohn
| Nature Verified
Abstract Mucosal-associated invariant T (MAIT) cells are donor unrestricted T cells capable of both antigen-specific adaptive responses and cytokine driven innate-like functions. Although human MAIT cells uniformly express RORγt and IL23R, they generally produce IFN-γ, and only a small fraction produces IL-17. Recent studies show that combined TCR and cytokine stimulation can elicit functional heterogeneity in blood-derived MAIT cells.
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Human Neonatal MR1T Cells Have Diverse TCR Usage, are Less Cytotoxic and are Unable to Respond to Many Common Childhood Pathogens.

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By Dylan Kain, Gw McElfresh, Wael Abdelhady, Meghan Cansler
| BioRxiv
Abstract Neonatal sepsis is a leading cause of childhood mortality. Understanding immune cell development can inform strategies to combat this. MR1-restricted T (MR1T) cells can be defined by their recognition of small molecules derived from microbes, self, and drug and drug-like molecules, presented by the MHC class 1-related molecule (MR1).
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Overlapping stimulons arising in response to divergent stresses in Escherichia coli

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By Huijing Wang, Gw McElfresh, Nishantha Wijesuriya, Adam R. Podgorny
| BioRxiv
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