Gyeong-Tak Byeon

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Dynamic Light Scattering for Assessing Aggregation in [177Lu]Lu-DOTA-Trastuzumab: A Quality Control Approach for Radioimmunotherapy

Jan 27, 2026 |

By Muhammad Ahmed Zeeshan, Gyeong-Tak Byeon, Huu Bao Nguyen, Aran Kim

| ACS Publications

Abstract Click to copy section linkSection link copied! Radioimmunotherapy (RIT) delivers radionuclides to tumors through antibody-based targeting. However, radiolabeling with high-linear energy transfer (LET) isotopes like Lu-177 can induce aggregation, reducing antibody stability and bioactivity.

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Dynamic Light Scattering for Assessing Aggregation in [177Lu]Lu-DOTA-Trastuzumab: A Quality Control Approach for Radioimmunotherapy

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