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Gyuho Jang on Muck Rack

Gyuho Jang

As seen in: Nature
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Articles

Golgi condensation causes intestinal lipid accumulation through HIF-1α-mediated GM130 ubiquitination by NEDD4 - Experimental & Molecular Medicine

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By Gyuho Jang, Hyug Moo Kwon, Channy Park
| Nature Verified
Abstract The breakdown of Golgi proteins disrupts lipid trafficking, leading to lipid accumulation in the small intestine. However, the causal mechanism of the effects of Golgi protein degradation on the Golgi structure related to lipid trafficking in the small intestine remains unknown. Here we find that Golgi protein degradation occurs under hypoxic conditions in high-fat-diet-fed mice. Hypoxia-induced degradation promotes structural changes in the Golgi apparatus, termed ‘Golgi condensation’.
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Spatial profiling of non-small cell lung cancer provides insights into tumorigenesis and immunotherapy response - Communications Biology

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By Joon T. Kim, Raekil Park, Hyun-Hee Koh, Chang-Myung Oh, Gyuho Jang
| Nature Verified
Abstract Lung cancer is the second most common cancer worldwide and a leading cause of cancer-related deaths. Despite advances in targeted therapy and immunotherapy, the prognosis remains unfavorable, especially in metastatic cases. This study aims to identify molecular changes in non-small cell lung cancer (NSCLC) patients based on their response to treatment.
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