Loading metrics Open Access Peer-reviewed Research Article Hadas Grouper , Martin Löffler, Herta Flor, Elon Eisenberg , Dorit Pud Hadas Grouper, Martin Löffler, Herta Flor, Elon Eisenberg, Dorit Pud Published: April 20, 2022 https://doi.org/10.1371/journal.pone.0267170 Abstract Background The representation of variability in sensitivity to pain by differences in neural connectivity patterns and its association with psychological factors needs further investigation.