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Hadassa Kwetsie

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Serum NfL, GFAP, and p-tau217 in adults with drug-resistant epilepsy and intellectual disabilities: Signs of ongoing neural injury

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By Amsterdam Reproduction, Hadassa Kwetsie, Inge M. W. Verberk
| Wiley Online Library Verified
Serum neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) are significantly elevated in more than half of adults with drug-resistant epilepsy and intellectual disability (ID) compared to healthy controls. Elevated NfL correlates with adaptive decline, suspected dementia, and higher seizure frequency. Unlike in the general elderly population, Alzheimer's pathology is rarely the driver of neural injury in this group.
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