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Hadiar Rahman on Muck Rack

Hadiar Rahman

As seen in: Nature, MDPI
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Articles

Advances in the structure, mechanism and targeting of chemoresistance-linked ABC transporters - Nature Reviews Cancer

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By Andaleeb Sajid, Hadiar Rahman, Suresh V. Ambudkar
| Nature Verified
Abstract Cancer cells frequently display intrinsic or acquired resistance to chemically diverse anticancer drugs, limiting therapeutic success. Among the main mechanisms of this multidrug resistance is the overexpression of ATP-binding cassette (ABC) transporters that mediate drug efflux, and, specifically, ABCB1, ABCG2 and ABCC1 are known to cause cancer chemoresistance.
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Residues from Homologous Transmembrane Helices 4 and 10 Are Critical for P-Glycoprotein (ABCB1)-Mediated Drug Transport

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By Mark Ware, Andaleeb Sajid, Sabrina Lusvarghi, Hadiar Rahman
| MDPI
Abstract : Simple Summary P-glycoprotein (P-gp, ABCB1) is an ATP-binding cassette (ABC) transporter that contributes to the development of multidrug resistance (MDR) in cancer cells. P-gp pumps various amphipathic agents including anticancer drugs out of cells. The elucidation of the P-gp mechanism of drug transport is critical to develop strategies to overcome MDR.
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