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Hadiya Manzoor

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Hypoxanthine—early biomarker of outcomes in an ovine model of neonatal hypoxic ischemic encephalopathy

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By Yasmine White, Rachel Hutchings, Christian Vento, Aijun Wang, Brian D Goudy, Satyan Lakshminrusimha, Michael Smith, Michaël Smith, Martina A. Steurer, Jeffrey R. Fineman, Donna M. Ferriero, Emin Maltepe, Jana K. Mike, Eesha Natarajan, Janica Ha, Ariana Iranmahboub, Hadiya Manzoor
| Nature Verified
Abstract Hypoxic-ischemic encephalopathy (HIE) is the leading cause of neonatal morbidity and mortality globally. An early tool to diagnose and prognosticate disease could aid in timely intervention and reduction in disease burden. We aimed to identify biomarkers for HIE and define whether these biomarkers are associated with neurologic outcome severity in our ovine model. Study Cohort 1 (n = 46) included lambs with HIE induced via umbilical cord occlusion (UCO) and healthy controls (n = 19).
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