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Hae Hyun Jung

As seen in: Nature, MDPI, Cell Reports Medicine
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Articles

Comparative analysis of EV isolation methods for mRNA profiling using the nCounter platform in breast cancer

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By Hae Hyun Jung, Eun Yoon Cho, Jeong Eon Lee, Seok Kim, Seok Jin Nam, Junghoon Shin, Yeon Hee Park, Jin Seok Ahn, Ji-Yeon Kim, Young-Hyuck Im
| Nature Verified
Abstract Extracellular vesicle-derived mRNAs (EV-mRNAs) are emerging analytes for liquid biopsy research, but their reliable detection is limited by low RNA abundance and co-isolated nucleic acids. We compared five EV isolation approaches to identify a suitable workflow for EV-mRNA profiling using the NanoString nCounter platform in breast cancer.
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Spatial and genomic profiling of residual breast cancer after neoadjuvant chemotherapy unveil divergent fates for each breast cancer subtype

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By Eun Seop Seo, Sabin Park, Eun Yoon Cho, Jeong Eon Lee, Hae Hyun Jung, Sepil An, Seok Kim, Junghoon Shin, Jin Seok Ahn, Yeon Hee Park, Young-Hyuck Im, Hoon Kim, Semin Lee, Woong-Yang Park, Ji-Yeon Kim, Jiyeon Hyeon
| Cell Reports Medicine Verified
STAR★Methods REAGENT or RESOURCESOURCEIDENTIFIER Antibodies ER Antibody Immunotech, Marseille, France Cat# IM1344; RRID: AB_131617 PgR Antibody Novocastra Laboratories Ltd., Newcastle upon Tyne, UK Cat# NCL-L-PGR-312; RRID:AB_563967 HER2 Antibody Dako, Glostrop, Denmark Cat# SK001; RRID:AB_2935822 Biological samples Human breast cancer samples Samsung Medical Center N/A Critical commercial assays QIAamp DNA Mini Kit Qiagen Cat# 51304 QIAamp DNA Blood Mini Kit Qiagen Cat# 51106 RNeasy Mini Kit...
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IJMS | Free Full-Text | A Retrospective Exploratory Analysis for Serum Extracellular Vesicles Reveals APRIL (TNFSF13), CXCL13, and VEGF-A as Prognostic Biomarkers for Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer

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By Hae Hyun Jung, Ji-Yeon Kim, Eun Yoon Cho, Jeong Eon Lee
| MDPI
1. Introduction Triple-negative breast cancer (TNBC), which is defined by the lack of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) expression, accounts for 15–20% of all breast cancers. TNBC is associated with a younger age of onset, more advanced stage, and poor prognosis compared to non-TNBCs. Due to the lack of therapeutic targets, cytotoxic chemotherapy is the only recommended systemic treatment strategy for patients with TNBC [1,2].
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