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Hai-Yan Yin on Muck Rack

Hai-Yan Yin

As seen in: Nature, Frontiers, Frontiers in Immunology, JAMA (The Journal of the American Medical Association), JAMA: Journal of the American Medical Association, Respiratory Research
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Articles

Lactate and lactylation in sepsis: regulation of immune-metabolic crosstalk and organ injury

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By Zhiwang Li, Wan-Jie Gu, Tao Li, Xiang-Jie Duan, Feng Yang, Hai-Yan Yin, Zhiming Zhang, Peiyu Li, Xingui Dai
| Frontiers in Immunology
Abstract Sepsis is a life−threatening organ dysfunction caused by a dysregulated host response to infection and remains a leading cause of death worldwide. Hyperlactatemia, a hallmark metabolic disorder in sepsis, has recently been recognized as an epigenetic modulator via lysine lactylation. This Review synthesizes the evolving understanding of lactate—from a prognostic biomarker to a pathogenic mediator and, most recently, to an epigenetic modulator through lysine lactylation (Kla).
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Focal neuropathologies in the brain of COVID-19-infected humans: inflammation, primary gliovascular failure and microglial dysfunction - Signal Transduction and Targeted Therapy Original

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By Peter Illes, Hai-Yan Yin, Yong Tang
| Nature Verified
Dénes and his co-workers recently published a paper in Nature Neuroscience, documenting that neurological abnormalities in COVID are based on microglial dysfunction in the brain.1 In case of acute respiratory syndrome of COVID infection, the central nervous system symptomatology significantly contribute to the severity of this disease.
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Association between the ROX index and mortality in patients with acute hypoxemic respiratory failure: a retrospective cohort study - Respiratory Research

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By Kai Liu, Xin-Yi Ma, Hua Xiao, Wan-Jie Gu, Jun Lyu, Hai-Yan Yin
| Respiratory Research Verified
We employed a retrospective cohort approach to investigate the association between the ROX index and mortality among adult patients with AHRF in ICU. The data utilized in this study was obtained from the MIMIC-IV version 2.0 database.
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