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Key Points Question Does preoperative intranasal oxytocin reduce the cumulative incidence of screening-positive probable acute stress disorder (ASD) within the first 3 postoperative days following traumatic fracture surgery? Findings In this randomized clinical trial of 328 patients, a single preoperative dose of intranasal oxytocin was associated with a lower 3-day cumulative incidence of screening-positive probable ASD compared with saline (15.9% vs 30.5%).
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