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Abstract Background: Suboptimal hepatobiliary-phase (HBP) enhancement may limit the diagnostic quality of gadoxetic acid-enhanced MRI. We investigated whether routinely available laboratory indicators and liver function scores could identify patients at increased risk of suboptimal HBP imaging. Methods: This retrospective study included 555 patients with focal liver lesions who underwent gadoxetic acid-enhanced MRI, including 460 with good and 95 with suboptimal HBP image quality.
Here, we review three sets of key proteins and their corresponding downstream pathways that have been linked to extending lifespan and promoting health span in a wide range of organisms. In particular, we review the biology of the sirtuin family of proteins, the insulin/insulin-like growth factor (IGF) signaling (IIS) pathway, and the mechanistic target of rapamycin (mTOR).
Here, we review three sets of key proteins and their corresponding downstream pathways that have been linked to extending lifespan and promoting health span in a wide range of organisms. In particular, we review the biology of the sirtuin family of proteins, the Insulin/Insulin-like Growth Factor (IGF) signaling (IIS) pathway, and the mechanistic Target of Rapamycin (mTOR).
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